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Article

PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer.

Journal of cell science - 15 Aug 2011

Johnson Emmanuel O, Chang Kuei-Hua, de Pablo Yolanda, Ghosh Soumitra, Mehta Rutika, Badve Sunil, Shah Kavita

Abstract excerpt

Aurora A kinase is overexpressed in the majority of breast carcinomas. A chemical genetic approach was used to identify the malignant targets of Aurora A, which revealed pleckstrin-homology-like domain protein PHLDA1 as an Aurora A substrate. PHLDA1 downregulation is a powerful prognostic predictor for breast carcinoma, which was confirmed in our study. We further show that downregulation of PHLDA1 is associated...

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Identifiers

PMID: 21807936
DOI: 10.1242/jcs.084970

Genes

PHLDA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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