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Article

Analysis of molecular aberrations of Wnt pathway gladiators in colorectal cancer in the Kashmiri population.

Human genomics - 1 Jul 2011

Syed Sameer A, Shah Zaffar A, Abdullah Safiya, Chowdri Nissar A, Siddiqi Mushtaq A

Abstract excerpt

The development and progression of colorectal cancer (CRC) is a multi-step process, and the Wnt pathways with its two molecular gladiators adenomatous polyposis coli (APC) and β-catenin plays an important role in transforming a normal tissue into a malignant one. In this study, we aimed to investigate the role of aberrations in the APC and β-catenin genes in the pathogenesis of CRC in the Kashmir valley, and to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21807601
DOI: 10.1186/1479-7364-5-5-441
PMCID: PMC3525962

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APC

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