Article
Allelic loss on chromosome 11 is uncommon in parathyroid glands of patients with hypercalcaemic secondary hyperparathyroidism.
The European journal of surgery = Acta chirurgica - 1 May 1997
Farnebo F, Farnebo L O, Nordenström J, Larsson C
Abstract excerpt
OBJECTIVE: To test the hypothesis that progression of secondary hyperparathyroidism from normocalcaemia to hypercalcaemia occurs because of development of monoclonal parathyroid tumours after the inactivation of a tumour suppressor gene on chromosome 11q13. DESIGN: Experimental study. SETTING: Un...
Topics
- Adolescent
- Adult
- Aged
- Alleles
- Child
- Chromosome Deletion
- Chromosomes, Human, Pair 11
- Disease Progression
- Female
- Heterozygote
- Humans
- Hypercalcemia
- Hyperparathyroidism, Secondary
- Hyperplasia
- Male
- Middle Aged
- Parathyroid Glands
