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Article

Allelic loss on chromosome 11 is uncommon in parathyroid glands of patients with hypercalcaemic secondary hyperparathyroidism.

The European journal of surgery = Acta chirurgica - 1 May 1997

Farnebo F, Farnebo L O, Nordenström J, Larsson C

Abstract excerpt

OBJECTIVE: To test the hypothesis that progression of secondary hyperparathyroidism from normocalcaemia to hypercalcaemia occurs because of development of monoclonal parathyroid tumours after the inactivation of a tumour suppressor gene on chromosome 11q13. DESIGN: Experimental study. SETTING: University hospital, Sweden. SUBJECTS: 13 Patients with secondary hypercalcaemic hyperparathyroidism. INTERVENTIONS: 48...

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Identifiers

PMID: 9195165

Genes

MEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allelic loss on chromosome 11 is uncommon in parathyroid glands of patients with hypercalcaemic secondary hyperparathyroidism.PMID 9195165Read ↗

Loss of heterozygosity in sporadic parathyroid tumours: involvement of chromosome 1 and the MEN1 gene locus in 11q13.Semantic proximity Read ↗

MEN1 gene alterations do not correlate with the phenotype of sporadic primary hyperparathyroidism.Semantic proximity Read ↗

Parathyroid MEN1 gene mutations in relation to clinical characteristics of nonfamilial primary hyperparathyroidism.Semantic proximity Read ↗

Involvement of the MEN1 gene locus in familial isolated hyperparathyroidism.Semantic proximity Read ↗

Somatic mutation of the MEN1 gene in parathyroid tumours.Semantic proximity Read ↗

Frequency of somatic MEN1 gene mutations in monoclonal parathyroid tumours of patients with primary hyperparathyroidism.Semantic proximity Read ↗

Localization of the MEN1 gene to a small region within chromosome 11q13 by deletion mapping in tumors.Semantic proximity Read ↗

Alterations of the MEN1 gene in sporadic parathyroid tumors.Semantic proximity Read ↗

MEN1 intragenic deletions may represent the most prevalent somatic event in sporadic primary hyperparathyroidism.Semantic proximity Read ↗

Progression of uremic hyperparathyroidism involves allelic loss on chromosome 11.Semantic proximity Read ↗

Familial isolated hyperparathyroidism maps to the hyperparathyroidism-jaw tumor locus in 1q21-q32 in a subset of families.Semantic proximity Read ↗

Carcinoid tumors frequently display genetic abnormalities involving chromosome 11.Semantic proximity Read ↗

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