Article
Increased expression of NKX2.3 mRNA transcribed from the risk haplotype for ulcerative colitis in the involved colonic mucosa.
Human immunology - 1 Jul 2011
Arai Takashi, Kakuta Yoichi, Kinouchi Yoshitaka, Kimura Tomoya, Negoro Kenichi, Aihara Hiroyuki, Endo Katsuya, Shiga Hisashi, Kanazawa Yoshitake, Kuroha Masatake, Moroi Rintaro, Nagasawa Hitoshi, Shimodaira Yosuke, Takahashi Seiichi, Shimosegawa Tooru
Abstract excerpt
NKX2.3 is a promising candidate for susceptibility genes to inflammatory bowel disease (IBD). The aim of this study was to perform a candidate gene analysis of NKX2.3 in Japanese IBD and to examine how the risk allele (haplotype) affects susceptibility to IBD using allelic expression ratios of NKX2.3 mRNA in the involved colonic mucosa. A total of 344 patients with Crohn's disease (CD), 253 patients with...
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