Article
Dendritic cells promote pancreatic viability in mice with acute pancreatitis.
Gastroenterology - 1 Nov 2011
Bedrosian Andrea S, Nguyen Andrew H, Hackman Michael, Connolly Michael K, Malhotra Ashim, Ibrahim Junaid, Cieza-Rubio Napoleon E, Henning Justin R, Barilla Rocky, Rehman Adeel, Pachter H Leon, Medina-Zea Marco V, Cohen Steven M, Frey Alan B, Acehan Devrim, Miller George
Abstract excerpt
BACKGROUND & AIMS: The cellular mediators of acute pancreatitis are incompletely understood. Dendritic cells (DCs) can promote or suppress inflammation, depending on their subtype and context. We investigated the roles of DC in development of acute pancreatitis. METHODS: Acute pancreatitis was induced in CD11c.DTR mice using caerulein or L-arginine; DCs were depleted by administration of diphtheria toxin....
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