Article
Mobile elements create structural variation: analysis of a complete human genome.
Genome research - 1 Sept 2009
Xing Jinchuan, Zhang Yuhua, Han Kyudong, Salem Abdel Halim, Sen Shurjo K, Huff Chad D, Zhou Qiong, Kirkness Ewen F, Levy Samuel, Batzer Mark A, Jorde Lynn B
Abstract excerpt
Structural variants (SVs) are common in the human genome. Because approximately half of the human genome consists of repetitive, transposable DNA sequences, it is plausible that these elements play an important role in generating SVs in humans. Sequencing of the diploid genome of one individual human (HuRef) affords us the opportunity to assess, for the first time, the impact of mobile elements on SVs in an...
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