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Article

Epigenetic Silencing of Nucleolar rRNA Genes in Alzheimer's Disease

22 Jul 2011

Abstract excerpt

BACKGROUND: Ribosomal deficits are documented in mild cognitive impairment (MCI), which often represents an early stage Alzheimer's disease (AD), as well as in advanced AD. The nucleolar rRNA genes (rDNA), transcription of which is critical for ribosomal biogenesis, are regulated by epigenetic silencing including promoter CpG methylation. METHODOLOGY/PRINCIPAL FINDINGS: To assess whether CpG methylation of the...

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PMID: 21799908
DOI: 10.1371/journal.pone.0022585

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