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Article

Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain.

PloS one - 7 May 2008

McGowan Patrick O, Sasaki Aya, Huang Tony C T, Unterberger Alexander, Suderman Matthew, Ernst Carl, Meaney Michael J, Turecki Gustavo, Szyf Moshe

Abstract excerpt

BACKGROUND: Alterations in gene expression in the suicide brain have been reported and for several genes DNA methylation as an epigenetic regulator is thought to play a role. rRNA genes, that encode ribosomal RNA, are the backbone of the protein synthesis machinery and levels of rRNA gene promoter methylation determine rRNA transcription. METHODOLOGY/PRINCIPAL FINDINGS: We test here by sodium bisulfite mapping of...

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Identifiers

PMID: 18461137
DOI: 10.1371/journal.pone.0002085
PMCID: PMC2330072

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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