Article
Molecular history of Richter syndrome: origin from a cell already present at the time of chronic lymphocytic leukemia diagnosis.
International journal of cancer - 15 Jun 2012
Rossi Davide, Spina Valeria, Forconi Francesco, Capello Daniela, Fangazio Marco, Rasi Silvia, Martini Maurizio, Gattei Valter, Ramponi Antonio, Larocca Luigi M, Bertoni Francesco, Gaidano Gianluca
Abstract excerpt
Richter syndrome (RS) represents the transformation of chronic lymphocytic leukemia to aggressive lymphoma. We explored intraclonal diversification (ID) of immunoglobulin genes in order to (i) follow the evolutionary history of the RS clone (ii) compare the role of ID in clonally related RS vs. clonally unrelated cases. Most (10/11, 90.9%) clonally related RS stem from the predominant clone observed at CLL...
Topics
- Cell Transformation, Neoplastic
- Genes, Immunoglobulin
- Genes, p53
- Humans
- Immunoglobulins
- Leukemia, Lymphocytic, Chronic, B-Cell
- Lymphoma
- Mutation
- Mutation Rate
- Tumor Suppressor Protein p53