The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation.

doi:10.1182/blood-2010-09-302174

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The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation.

Blood - 24 Mar 2011

Rossi Davide, Spina Valeria, Deambrogi Clara, Rasi Silvia, Laurenti Luca, Stamatopoulos Kostas, Arcaini Luca, Lucioni Marco, Rocque Gabrielle B, Xu-Monette Zijun Y, Visco Carlo, Chang Julie, Chigrinova Ekaterina, Forconi Francesco, Marasca Roberto, Besson Caroline, Papadaki Theodora, Paulli Marco, Larocca Luigi M, Pileri Stefano A, Gattei Valter, Bertoni Francesco, Foà Robin, Young Ken H, Gaidano Gianluca

Abstract excerpt

Richter syndrome (RS) represents the development of diffuse large B-cell lymphoma in the context of chronic lymphocytic leukemia. The scarcity of biologic information about RS has hampered the identification of molecular predictors of RS outcome. We addressed this issue by performing a comprehensive molecular characterization of 86 pathologically proven RS. TP53 disruption (47.1%) and c-MYC abnormalities (26.2%)...

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PMID: 21266718
DOI: 10.1182/blood-2010-09-302174

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