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IgVH Mutational Status and Clonality Analysis of Richter's Transformation

1 Oct 2007

Abstract excerpt

Approximately 5% of B-cell chronic lymphocytic leukemia (B-CLL) patients develop a secondary aggressive lymphoma, usually of diffuse large B-cell type (DLBCL), termed Richter's transformation (RT). Rarely, classic Hodgkin lymphoma (HL) is observed. Published small series suggest that tumor cells in DLBCL and HL can be clonally identical to the B-CLL clone or arise as an independent, secondary lymphoma. We...

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PMID: 17895764
DOI: 10.1097/pas.0b013e31804bdaf8

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