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Richter syndrome: molecular insights and clinical perspectives

10 Feb 2009

Abstract excerpt

Richter syndrome (RS) represents the clinico-pathologic transformation of chronic lymphocytic leukaemia (CLL) to an aggressive lymphoma, most commonly diffuse large B-cell lymphoma (DLBCL). The clinical definition of RS is heterogeneous, and encompasses at least two biologically different conditions: (i) CLL transformation to a clonally related DLBCL, that accounts for the majority of cases; (ii) development of a...

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PMID: 19206112
DOI: 10.1002/hon.880

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