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Richter syndrome: Novel insights into the biology of transformation

9 Feb 2023

Abstract excerpt

Although the genetic landscape of chronic lymphocytic leukemia (CLL) has been broadly profiled by large-scale sequencing studies performed over the past decade, the molecular basis of the transformation of CLL into aggressive lymphoma, or Richter syndrome (RS), has remained incompletely characterized. Recent advances in computational methods of clonal deconvolution, as well as extensive sample collection efforts...

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PMID: 36758208
DOI: 10.1182/blood.2022016502

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