Article
Clonally unrelated Richter syndrome are truly de novo diffuse large B-cell lymphomas with a mutational profile reminiscent of clonally related Richter syndrome.
British journal of haematology - 1 Sept 2022
Favini Chiara, Talotta Donatella, Almasri Mohammad, Andorno Annalisa, Rasi Silvia, Adhinaveni Ramesh, Kogila Sreekar, Awikeh Bassel, Schipani Mattia, Boggione Paola, Mouhssine Samir, Ghanej Joseph, Al Essa Wael, Mahmoud Abdurraouf Mokhtar, Dondolin Riccardo, Alessa Nariman, Margiotta Casaluci Gloria, Boldorini Renzo, Gattei Valter, Gaidano Gianluca, Moia Riccardo
Abstract excerpt
Richter syndrome (RS) is mostly due to the direct transformation of the chronic lymphocytic leukaemia (CLL) clone, as documented by the same immunoglobulin heavy-chain variable region (IGHV) rearrangement in both CLL and RS cells. In rare cases characterized by a better outcome, the RS clone harbours a different IGHV rearrangement compared to the CLL phase. We investigated the CLL phase of clonally unrelated RS...
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