Article
Association of common variants, not rare mutations, in IRF6 with nonsyndromic clefts in a Honduran population.
The Laryngoscope - 1 Aug 2011
Larrabee Yuna C, Birkeland Andrew C, Kent David T, Flores Carlos, Su Gloria H, Lee Joseph H, Haddad Joseph
Abstract excerpt
OBJECTIVES/HYPOTHESIS: Cleft lip with or without cleft palate (CL/P) is a common birth defect throughout the world. Linkage studies have shown interferon regulatory factor 6 (IRF6) to be associated with CL/P in multiple populations, including one in Honduras. It is unknown, however, whether rare sporadic mutations or common variants are the cause of this association, and reports exist supporting both hypotheses....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.