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<i>in vivo</i> Variation in Metabotropic Glutamate Receptor Subtype 5 Binding Using Positron Emission Tomography and [ <sup>11</sup> C]ABP688

27 Jul 2011

Abstract excerpt

The metabotropic glutamate receptor subtype 5 (mGluR5) has been implicated in the pathophysiology of mood and anxiety disorders. Recently, a positron emission tomography (PET) tracer exhibiting high selectivity and specificity for mGluR5, 3-(6-methyl-pyridin-2-ylethynyl)-cyclohex-2-enone-O-(11)C-methyl-oxime ([(11)C]ABP688), was developed. In this work, eight healthy adult male humans were imaged twice to assess...

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PMID: 21792244
DOI: 10.1038/jcbfm.2011.105

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