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Fenfluramine evokes 5‐HT<sub>2A</sub> receptor‐mediated responses but does not displace [<sup>11</sup>C]MDL 100907: Small animal PET and gene expression studies

22 Sept 2003

Abstract excerpt

The in vivo binding of the 5-HT(2A) receptor-selective positron emission tomography (PET) ligand [(11)C]MDL 100907 and its sensitivity to endogenous 5-HT were quantified in rat brain using quad-HIDAC, a novel high-resolution PET camera for small animals. Specific binding of [(11)C]MDL 100907, estimated using volume of interest (VOI) to cerebellum ratios, corresponded well with both the known distribution of...

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PMID: 14515343
DOI: 10.1002/syn.10268

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