Article
Germline mutations in MSR1, ASCC1, and CTHRC1 in patients with Barrett esophagus and esophageal adenocarcinoma.
JAMA - 27 Jul 2011
Orloff Mohammed, Peterson Charissa, He Xin, Ganapathi Shireen, Heald Brandie, Yang Yi-ran, Bebek Gurkan, Romigh Todd, Song Jee Hoon, Wu Wenjing, David Stefan, Cheng Yulan, Meltzer Stephen J, Eng Charis
Abstract excerpt
CONTEXT: Barrett esophagus (BE) occurs in 1% to 10% of the general population and is believed to be the precursor of esophageal adenocarcinoma (EAC). The incidence of EAC has increased 350% in the last 3 decades without clear etiology. Finding predisposition genes may improve premorbid risk assessment, genetic counseling, and management. Genome-wide multiplatform approaches may lead to the identification of genes...
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