Article
Sex-Specific Genetic Associations for Barrett's Esophagus and Esophageal Adenocarcinoma.
Gastroenterology - 1 Dec 2020
Dong Jing, Maj Carlo, Tsavachidis Spiridon, Ostrom Quinn T, Gharahkhani Puya, Anderson Lesley A, Wu Anna H, Ye Weimin, Bernstein Leslie, Borisov Oleg, Schröder Julia, Chow Wong-Ho, Gammon Marilie D, Liu Geoffrey, Caldas Carlos, Pharoah Paul D, Risch Harvey A, May Andrea, Gerges Christian, Anders Mario, Venerito Marino, Schmidt Thomas, Izbicki Jakob R, Hölscher Arnulf H, Schumacher Brigitte, Vashist Yogesh, Neuhaus Horst, Rösch Thomas, Knapp Michael, Krawitz Peter, Böhmer Anne, Iyer Prasad G, Reid Brian J, Lagergren Jesper, Shaheen Nicholas J, Corley Douglas A, Gockel Ines, Fitzgerald Rebecca C, Cook Michael B, Whiteman David C, Vaughan Thomas L, Schumacher Johannes, Thrift Aaron P
Abstract excerpt
BACKGROUND & AIMS: Esophageal adenocarcinoma (EA) and its premalignant lesion, Barrett's esophagus (BE), are characterized by a strong and yet unexplained male predominance (with a male-to-female ratio in EA incidence of up to 6:1). Genome-wide association studies (GWAS) have identified more than 20 susceptibility loci for these conditions. However, potential sex differences in genetic associations with BE/EA...
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