Article
Germline variant in MSX1 identified in a Dutch family with clustering of Barrett's esophagus and esophageal adenocarcinoma.
Familial cancer - 1 Jul 2018
van Nistelrooij A M J, van Marion R, van Ijcken W F J, de Klein A, Wagner A, Biermann K, Spaander M C W, van Lanschot J J B, Dinjens W N M, Wijnhoven B P L
Abstract excerpt
The vast majority of esophageal adenocarcinoma cases are sporadic and caused by somatic mutations. However, over the last decades several families have been identified with clustering of Barrett's esophagus and esophageal adenocarcinoma. This observation suggests that one or more hereditary factors may play a role in the initiation of Barrett's esophagus and esophageal adenocarcinoma in these families. A Dutch...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.