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Article

Impaired fitness of Mycobacterium tuberculosis resistant isolates in a cell culture model of murine macrophages.

The Journal of antimicrobial chemotherapy - 1 Oct 2011

Rey-Jurado Emma, Tudó Griselda, Borrell Sònia, Alcaide Fernando, Coll Pere, Español Montserrat, Martín-Casabona Núria, Mick Virginie, Montemayor Michel, Moure Raquel, Salvadó Margarita, Vicente Eva, González-Martín Julià

Abstract excerpt

OBJECTIVES: We analysed the ability of Mycobacterium tuberculosis clinical isolates to penetrate and grow inside murine macrophages as a surrogate of fitness. METHODS: Thirty-five drug-resistant and 10 drug-susceptible M. tuberculosis isolates were studied in a murine macrophage model from the J774.2 cell line in a 6 day protocol, performing semi-quantitative counts in Middlebrook 7H11 medium. The mycobacterial...

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PMID: 21791442
DOI: 10.1093/jac/dkr288

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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