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Article

Time-kill kinetics of anti-tuberculosis drugs, and emergence of resistance, in relation to metabolic activity of Mycobacterium tuberculosis.

The Journal of antimicrobial chemotherapy - 1 Dec 2010

de Steenwinkel Jurriaan E M, de Knegt Gerjo J, ten Kate Marian T, van Belkum Alex, Verbrugh Henri A, Kremer Kristin, van Soolingen Dick, Bakker-Woudenberg Irma A J M

Abstract excerpt

OBJECTIVES: The pharmacodynamics of tuberculosis (TB) treatment should be further explored, to prevent emergence of resistance, treatment failure and relapse of infection. The diagnostic drug susceptibility tests guiding TB therapy investigate metabolically active Mycobacterium tuberculosis (Mtb) isolates under static conditions and as such are not informative with respect to the time-kill kinetics of anti-TB...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20947621
DOI: 10.1093/jac/dkq374

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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