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Article

Polymorphisms in catechol-O-methyltransferase and methylenetetrahydrofolate reductase in relation to the risk of schizophrenia.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Feb 2008

Muntjewerff Jan-Willem, Gellekink Henkjan, den Heijer Martin, Hoogendoorn Mechteld L C, Kahn René S, Sinke Richard J, Blom Henk J

Abstract excerpt

BACKGROUND: Evidence is emerging for the association of aberrant homocysteine-methylation cycle and increased risk of schizophrenia. METHODS: We examined the prevalence of the catechol-O-methyltransferase (COMT) 324G>A (Val108/158Met) and methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphisms in 252 patients with schizophrenia and 405 control subjects. All subjects were of Dutch ancestry. RESULTS: The...

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Source

Identifiers

PMID: 17716874
DOI: 10.1016/j.euroneuro.2007.06.005

Genes

COMT
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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