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Article

Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models.

PloS one - 24 May 2010

Sei Yoshitatsu, Li Zhen, Song Jian, Ren-Patterson Renee, Tunbridge Elizabeth M, Iizuka Yukihiko, Inoue Masahiro, Alfonso Berenice T, Beltaifa Senda, Nakai Yoko, Kolachana Bhaskar S, Chen Jingshan, Weinberger Daniel R

Abstract excerpt

BACKGROUND: Neuregulin1 (NRG1)-ErbB signaling has been implicated in the pathogenesis of cancer and schizophrenia. We have previously reported that NRG1-stimulated migration of B lymphoblasts is PI3K-AKT1dependent and impaired in patients with schizophrenia and significantly linked to the catecho...

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Share to B-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Activation

Share to Epistasis, Genetic

Share to Neuregulin-1

Share to Phosphatidylinositol Phosphates

Share to Phosphatidylserines

Share to Proto-Oncogene Proteins c-akt

Source

Open in PubMed Open full text

Identifiers

PMID: 20520724
DOI: 10.1371/journal.pone.0010789
PMCID: PMC2875391

Genes

AKT1
COMT
NRG1
PIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20520724-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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