Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced Renewal of Erythroid Progenitors in Myelodysplastic Anemia by Peripheral Serotonin

1 Mar 2019

Abstract excerpt

Tryptophan as the precursor of several active compounds, including kynurenine and serotonin, is critical for numerous important metabolic functions. Enhanced tryptophan metabolism toward the kynurenine pathway has been associated with myelodysplastic syndromes (MDSs), which are preleukemic clonal diseases characterized by dysplastic bone marrow and cytopenias. Here, we reveal a fundamental role for tryptophan...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to Acute Myeloid Leukemia Research
Share to Myeloproliferative Neoplasms: Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30893598
DOI: 10.1016/j.celrep.2019.02.071

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Enhanced Renewal of Erythroid Progenitors in Myelodysplastic Anemia by Peripheral SerotoninPMID 30893598Read ↗

Ineffective erythropoiesis with reduced red blood cell survival in serotonin-deficient mice.Semantic proximity Read ↗

Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR–RUNX1Semantic proximity Read ↗

The Kynurenine Pathway in Stem Cell BiologySemantic proximity Read ↗

The Role of Serotonin in Breast Cancer Stem Cells.Semantic proximity Read ↗

Type I interferon-mediated skewing of the serotonin synthesis is associated with severe disease in systemic lupus erythematosus.Semantic proximity Read ↗

Tryptophan hydroxylase 2 (TPH2) in a neuronal cell line: modulation by cell differentiation and NRSF/rest activity.Semantic proximity Read ↗

Modulation of novel drug targets in neurotransmitter signalling to eradicate leukaemic stem cells in chronic myeloid leukaemiaSemantic proximity Read ↗

Optimized derivation and functional characterization of 5-HT neurons from human embryonic stem cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.