Article
Constitutively Elevated Blood Serotonin Is Associated with Bone Loss and Type 2 Diabetes in Rats.
PloS one - 1 Jan 2016
Erjavec Igor, Bordukalo-Niksic Tatjana, Brkljacic Jelena, Grcevic Danka, Mokrovic Gordana, Kesic Maja, Rogic Dunja, Zavadoski William, Paralkar Vishwas M, Grgurevic Lovorka, Trkulja Vladimir, Cicin-Sain Lipa, Vukicevic Slobodan
Abstract excerpt
Reduced peripheral serotonin (5HT) in mice lacking tryptophan hydroxylase (TPH1), the rate limiting enzyme for 5HT synthesis, was reported to be anabolic to the skeleton. However, in other studies TPH1 deletion either had no bone effect or an age dependent inhibition of osteoclastic bone resorption. The role of 5HT in bone therefore remains poorly understood. To address this issue, we used selective breeding to...
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