Article
Inhibition of Navβ4 peptide-mediated resurgent sodium currents in Nav1.7 channels by carbamazepine, riluzole, and anandamide.
Molecular pharmacology - 1 Oct 2011
Theile Jonathan W, Cummins Theodore R
Abstract excerpt
Paroxysmal extreme pain disorder (PEPD) and inherited erythromelalgia (IEM) are inherited pain syndromes arising from different sets of gain-of-function mutations in the sensory neuronal sodium channel isoform Nav1.7. Mutations associated with PEPD, but not IEM, result in destabilized inactivatio...
Topics
- Action Potentials
- Arachidonic Acids
- Carbamazepine
- Endocannabinoids
- Erythromelalgia
- HEK293 Cells
- Humans
- Mutation
- NAV1.7 Voltage-Gated Sodium Channel
- Polyunsaturated Alkamides
- Riluzole
- Sodium Channel Blockers
- Sodium Channels
- Voltage-Gated Sodium Channel beta-4 Subunit