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Article

Open-channel block by the cytoplasmic tail of sodium channel beta4 as a mechanism for resurgent sodium current.

Neuron - 20 Jan 2005

Grieco Tina M, Malhotra Jyoti D, Chen Chunling, Isom Lori L, Raman Indira M

Abstract excerpt

Voltage-gated sodium channels with "resurgent" kinetics are specialized for high-frequency firing. The alpha subunits interact with a blocking protein that binds open channels upon depolarization and unbinds upon repolarization, producing resurgent sodium current. By limiting classical inactivati...

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Identifiers

PMID: 15664175
DOI: 10.1016/j.neuron.2004.12.035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15664175-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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