Article
Open-channel block by the cytoplasmic tail of sodium channel beta4 as a mechanism for resurgent sodium current.
Neuron - 20 Jan 2005
Grieco Tina M, Malhotra Jyoti D, Chen Chunling, Isom Lori L, Raman Indira M
Abstract excerpt
Voltage-gated sodium channels with "resurgent" kinetics are specialized for high-frequency firing. The alpha subunits interact with a blocking protein that binds open channels upon depolarization and unbinds upon repolarization, producing resurgent sodium current. By limiting classical inactivation, the cycle of block and unblock shortens refractory periods. To characterize the blocker in Purkinje neurons, we...
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