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Article

Ranolazine selectively blocks persistent current evoked by epilepsy-associated Naν1.1 mutations.

British journal of pharmacology - 1 Nov 2010

Kahlig Kristopher M, Lepist Irene, Leung Kwan, Rajamani Sridharan, George Alfred L

Abstract excerpt

BACKGROUND AND PURPOSE: Mutations of SCN1A, the gene encoding the pore-forming subunit of the voltage-gated sodium channel Na(V) 1.1, have been associated with a spectrum of genetic epilepsies and a familial form of migraine. Several mutant Na(V) 1.1 channels exhibit increased persistent current due to incomplete inactivation and this biophysical defect may contribute to altered neuronal excitability in these...

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Identifiers

PMID: 20735403
DOI: 10.1111/j.1476-5381.2010.00976.x
PMCID: PMC3000664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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