Article
Reverse pharmacogenomics: carbamazepine normalizes activation and attenuates thermal hyperexcitability of sensory neurons due to Nav 1.7 mutation I234T.
British journal of pharmacology - 1 Jun 2018
Yang Yang, Adi Talia, Effraim Philip R, Chen Lubin, Dib-Hajj Sulayman D, Waxman Stephen G
Abstract excerpt
BACKGROUND AND PURPOSE: Pharmacotherapy for pain currently involves trial and error. A previous study on inherited erythromelalgia (a genetic model of neuropathic pain due to mutations in the sodium channel, Nav 1.7) used genomics, structural modelling and biophysical and pharmacological analyses to guide pharmacotherapy and showed that carbamazepine normalizes voltage dependence of activation of the Nav...
Topics
- Carbamazepine
- HEK293 Cells
- Humans
- Models, Molecular
- Mutation
- NAV1.7 Voltage-Gated Sodium Channel
- Pharmacogenetics
- Sensory Receptor Cells
- Temperature