Differential effect of lacosamide on Nav1.7 variants from responsive and non-responsive patients with small fibre neuropathy.

doi:10.1093/brain/awaa016

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Differential effect of lacosamide on Nav1.7 variants from responsive and non-responsive patients with small fibre neuropathy.

Brain : a journal of neurology - 1 Mar 2020

Labau Julie I R, Estacion Mark, Tanaka Brian S, de Greef Bianca T A, Hoeijmakers Janneke G J, Geerts Margot, Gerrits Monique M, Smeets Hubert J M, Faber Catharina G, Merkies Ingemar S J, Lauria Giuseppe, Dib-Hajj Sulayman D, Waxman Stephen G

Abstract excerpt

Small fibre neuropathy is a common pain disorder, which in many cases fails to respond to treatment with existing medications. Gain-of-function mutations of voltage-gated sodium channel Nav1.7 underlie dorsal root ganglion neuronal hyperexcitability and pain in a subset of patients with small fibre neuropathy. Recent clinical studies have demonstrated that lacosamide, which blocks sodium channels in a...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Cells, Cultured
Humans
Lacosamide
Membrane Potentials
Middle Aged
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

NAV1.7 Voltage-Gated Sodium Channel

Pain

Pain Measurement

Patch-Clamp Techniques

Small Fiber Neuropathy

Sodium Channel Blockers

Treatment Outcome

Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 32011655
DOI: 10.1093/brain/awaa016
PMCID: PMC7089662

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-32011655-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential effect of lacosamide on Nav1.7 variants from responsive and non-responsive patients with small fibre neuropathy.PMID 32011655Read ↗

Efficacy, safety, and tolerability of lacosamide in patients with gain-of-function Nav1.7 mutation-related small fiber neuropathy: study protocol of a randomized controlled trial-the LENSS study.Semantic proximity Read ↗

Preclinical Animal Models to Investigate the Role of Nav1.7 Ion Channels in PainSemantic proximity Read ↗

Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief.Semantic proximity Read ↗

Discovery of a Selective, State-Independent Inhibitor of Na <sub>V</sub> 1.7 by Modification of Guanidinium ToxinsSemantic proximity Read ↗

Genetic aspects of sodium channelopathy in small fiber neuropathy.Semantic proximity Read ↗

Depolarized inactivation overcomes impaired activation to produce DRG neuron hyperexcitability in a Nav1.7 mutation in a patient with distal limb pain.Semantic proximity Read ↗

Effects of ranolazine on wild-type and mutant hNav1.7 channels and on DRG neuron excitability.Semantic proximity Read ↗

The G1662S NaV1.8 mutation in small fibre neuropathy: impaired inactivation underlying DRG neuron hyperexcitability.Semantic proximity Read ↗

Functional profiles of SCN9A variants in dorsal root ganglion neurons and superior cervical ganglion neurons correlate with autonomic symptoms in small fibre neuropathy.Semantic proximity Read ↗

Towards development of Nav1.7 channel modulators for pain treatment: A comparison of mexiletine effect in two cell models by automated patch clampSemantic proximity Read ↗

Gain-of-function Nav1.8 mutations in painful neuropathy.Semantic proximity Read ↗

Small nerve fibres, small hands and small feet: a new syndrome of pain, dysautonomia and acromesomelia in a kindred with a novel NaV1.7 mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.