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Article

Diverse transcriptomic and mutational patterns but limited functional pathway alterations in patient-derived Sézary syndrome cells.

The Journal of investigative dermatology - 1 Aug 2026

Andrades Evelyn, Iglesias Arnau, Maqueda María, Lobo-Jarne Teresa, González Jessica, Bertran Joan, Conde David, Rodriguez Eva, Bellosillo Beatriz, Pujol Ramon M, Bigas Anna, Espinosa Lluís, Gallardo Fernando

Abstract excerpt

Eradication of Sézary syndrome (SS) is hampered by genetic and molecular heterogeneity. A better understanding of the putative commonalities underlying SS oncogenicity may help to provide more efficient therapies against this disease. This work analyzes the whole transcriptome of different patient-derived SS cells (n = 7) to identify expression patterns and mutational profiles that may provide clues on new...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41644084
DOI: 10.1016/j.jid.2026.01.018

Genes

MALT1
BCL10
CARD11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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