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Article

Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire

29 Oct 2009

Abstract excerpt

Antibody repertoire diversity, potentially as high as 10(11) unique molecules in a single individual, confounds characterization by conventional sequence analyses. In this study, we present a general method for assessing human antibody sequence diversity displayed on phage using massively parallel pyrosequencing, a novel application of Kabat column-labeled profile Hidden Markov Models, and translated...

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PMID: 19875695
DOI: 10.1073/pnas.0909775106

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