[Restriction analysis of genome composition of live influenza vaccine].

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Article

[Restriction analysis of genome composition of live influenza vaccine].

Voprosy virusologii - 1 Jan 2000

Kiseleva I V, Larionova N V, Teley L C P, Rudenko L G

Abstract excerpt

Live attenuated cold-adapted influenza vaccine (LIV) has been used in Russia for over 50 years and proved to be safe and effective. Currently, Russian reassortant LAIV is based on influenza AILeningrad/134/17/57 (H2N2) and B/USSR/60/69 Master Donor Viruses (MDVs) which are cold-adapted (ca), temperature-sensitive (ts), and attenuated (att), respectively. The MDVs are used to generate attenuated reassortant...

Topics

Adaptation, Physiological
Animals
Biological Assay
Chick Embryo
Cold Temperature
DNA Primers
DNA Restriction Enzymes
Genome, Viral
Hemagglutination Inhibition Tests
Humans
Influenza A Virus, H1N1 Subtype
Influenza A Virus, H2N2 Subtype
Influenza B virus
Influenza Vaccines
Influenza, Human
Pandemics
Phenotype
Polymorphism, Restriction Fragment Length

Source

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Identifiers

PMID: 21786624

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