Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Application of real time RT-PCR for the genetic homogeneity and stability tests of the seed candidates for live attenuated influenza vaccine production.

Journal of virological methods - 1 Jan 2014

Shcherbik Svetlana, Sergent Sheila B, Davis William G, Shu Bo, Barnes John, Kiseleva Irina, Larionova Natalie, Klimov Alexander, Bousse Tatiana

Abstract excerpt

Development and improvement of quality control tests for live attenuated vaccines are a high priority because of safety concerns. Live attenuated influenza vaccine (LAIV) viruses are 6:2 reassortants containing the hemagglutinin (HA) and neuraminidase (NA) gene segments from circulating influenza viruses to induce protective immune responses, and the six internal gene segments from a cold-adapted Master Donor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chick Embryo
Share to Genomic Instability

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Influenza Vaccines

Share to Orthomyxoviridae

Share to Quality Control

Share to Real-Time Polymerase Chain Reaction

Share to Vaccines, Attenuated

Share to Virology

Source

Open in PubMed Open full text

Identifiers

PMID: 24056261
DOI: 10.1016/j.jviromet.2013.09.003
PMCID: PMC4607041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Application of real time RT-PCR for the genetic homogeneity and stability tests of the seed candidates for live attenuated influenza vaccine production.PMID 24056261Read ↗

Molecular signature of high yield (growth) influenza a virus reassortants prepared as candidate vaccine seeds.Semantic proximity Read ↗

Development of a high-yield reassortant influenza vaccine virus derived from the A/Anhui/1/2013 (H7N9) strainSemantic proximity Read ↗

Live Attenuated Influenza Vaccine contains Substantial and Unexpected Amounts of Defective Viral Genomic RNASemantic proximity Read ↗

Evaluation of a Genetically Modified Reassortant H5N1 Influenza A Virus Vaccine Candidate Generated by Plasmid-Based Reverse GeneticsSemantic proximity Read ↗

PCR restriction analysis of genome composition and stability of cold-adapted reassortant live influenza vaccines.Semantic proximity Read ↗

Development of an Influenza A Master Virus for Generating High-Growth Reassortants for A/Anhui/1/2013(H7N9) Vaccine Production in Qualified MDCK Cells.Semantic proximity Read ↗

Rationally Designed Influenza Virus Vaccines That Are Antigenically Stable during Growth in Eggs.Semantic proximity Read ↗

Self-Amplifying RNA Vaccines Give Equivalent Protection against Influenza to mRNA Vaccines but at Much Lower DosesSemantic proximity Read ↗

Genotyping assay for differentiation of wild-type and vaccine viruses in subjects immunized with live attenuated influenza vaccine.Semantic proximity Read ↗

Gene constellation of influenza A virus reassortants with high growth phenotype prepared as seed candidates for vaccine production.Semantic proximity Read ↗

[Live cold-adapted influenza vaccine: state-of-the-art].Semantic proximity Read ↗

Genotypic stability of cold-adapted influenza virus vaccine in an efficacy clinical trial.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.