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Article

Phenotypic Effects of Homeodomain-Interacting Protein Kinase 2 Deletion in Mice.

International journal of molecular sciences - 2 Aug 2021

De Biase Davide, Valente Valeria, Conte Andrea, Cammarota Francesca, Boccella Nicola, D'Esposito Lucia, d'Aquino Ilaria, Paciello Orlando, Paladino Simona, Pierantoni Giovanna Maria

Abstract excerpt

Homeodomain-interacting protein kinase 2 (HIPK2) is a serine-threonine kinase that phosphorylates various transcriptional and chromatin regulators, thus modulating numerous important cellular processes, such as proliferation, apoptosis, DNA damage response, and oxidative stress. The role of HIPK2 in the pathogenesis of cancer and fibrosis is well established, and evidence of its involvement in the homeostasis of...

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Identifiers

PMID: 34361060
DOI: 10.3390/ijms22158294
PMCID: PMC8348407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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