Article
Alterations in SV40 DNA integration patterns are associated with acquisition of the invasive phenotype in hamster brain tumors.
Anticancer research - 1 Jan 2000
Duigou G J, Walsh J W, Oeltgen J, Zimmer S G
Abstract excerpt
A panel of cell lines that represents a reproducible, easily manipulated experimental system which discriminates between the minimally and diffusely invasive phenotypes of brain tumors has been developed. A population of SV40-transformed glial cells derived from newborn hamster cerebral cortex (Cx) has been sequentially passaged in newborn hamsters by intracerebral inoculation followed by in vitro culture, and...
Topics
- Animals
- Blotting, Southern
- Brain Neoplasms
- Cell Line
- Cell Transformation, Neoplastic
- Cells, Cultured
- Cerebral Cortex
- Cricetinae
- DNA, Viral
- Neoplasm Invasiveness
- Nucleic Acid Hybridization