Spontaneous phenotypic and karyotypic progression in the SV40 transfected cell line SVG during prolonged passage in vitro.

doi:10.1007/BF00182082

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Article

Spontaneous phenotypic and karyotypic progression in the SV40 transfected cell line SVG during prolonged passage in vitro.

Journal of neuro-oncology - 1 Feb 1990

Davey P, Rauth A M, Mason L, Addy L

Abstract excerpt

Transfection of primary cultures of human cells with origin of replication deficient SV40 DNA has been carried out by others to generate in vitro models of malignant transformation in vivo. The present work describes progressive alterations in karyotype and phenotype in one such transfected (neur...

Topics

Animals
Antigens, Polyomavirus Transforming
Cell Line
Glial Fibrillary Acidic Protein
Glioma
Humans
Immunohistochemistry
Karyotyping
Male
Mice
Mice, Inbred CBA
Phenotype
Simian virus 40
Transfection

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