Article
Transgenes encoding mutant simian virus 40 large T antigens unmask phenotypic and functional constraints in thymic epithelial cells.
Oncogene - 1 Nov 1992
Moll J, Eibel H, Botteri F, Sansig G, Regnier C, van der Putten H
Abstract excerpt
Transgenes encoding simian virus 40 (SV40) T antigen (Tag) can cause hyperplastic or tumorigenic lesions of desired but also of unforeseen cellular origin. Unexpectedly the human growth hormone-releasing factor (GRF) gene promoter directs expression of SV40 Tag specifically in thymic epithelial (...
Topics
- Animals
- Antigens, Polyomavirus Transforming
- Cell Differentiation
- Epithelial Cells
- Growth Hormone-Releasing Hormone
- Interleukin-4
- Macrophage Colony-Stimulating Factor
- Mice
- Mice, Inbred C57BL
- Mutation
- Phenotype
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-kit
- Receptors, Interleukin-4
- Receptors, Mitogen
- Simian virus 40
- Temperature
- Thymus Gland