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Article

A Role for PML in Innate Immunity

1 Jan 2011

Abstract excerpt

The promyelocytic leukemia gene (PML) of acute promyelocytic leukemia is an established tumor suppressor gene with critical functions in growth suppression, induction of apoptosis, and cellular senescence. Interestingly, although less studied, PML seems to play a key role also in immune response to viral infection. Herein, we report that Pml(-/-) mice spontaneously develop an atypical invasive and lethal...

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Identifiers

PMID: 21779477
DOI: 10.1177/1947601911402682

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