Article
Deficient zebrafish ether-à-go-go-related gene channel gating causes short-QT syndrome in zebrafish reggae mutants.
Circulation - 19 Feb 2008
Hassel David, Scholz Eberhard P, Trano Nicole, Friedrich Oliver, Just Steffen, Meder Benjamin, Weiss Daniel L, Zitron Edgar, Marquart Sabine, Vogel Britta, Karle Christoph A, Seemann Gunnar, Fishman Mark C, Katus Hugo A, Rottbauer Wolfgang
Abstract excerpt
BACKGROUND: Genetic predisposition is believed to be responsible for most clinically significant arrhythmias; however, suitable genetic animal models to study disease mechanisms and evaluate new treatment strategies are largely lacking. METHODS AND RESULTS: In search of suitable arrhythmia models, we isolated the zebrafish mutation reggae (reg), which displays clinical features of the malignant human short-QT...
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