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Article

Highly conserved O-fucose sites have distinct effects on Notch1 function.

The Journal of biological chemistry - 16 Sept 2005

Rampal Raajit, Arboleda-Velasquez Joseph F, Nita-Lazar Alexandra, Kosik Kenneth S, Haltiwanger Robert S

Abstract excerpt

The extracellular domain of mouse Notch1 contains 36 tandem epidermal growth factor-like (EGF) repeats, many of which are modified with O-fucose. Previous work from several laboratories has indicated that O-fucosylation plays an important role in ligand mediated Notch activation. Nonetheless, it is not clear whether all, or a subset, of the EGF repeats need to be O-fucosylated. Three O-fucose sites are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15994302
DOI: 10.1074/jbc.M506104200
PMCID: PMC1242041

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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