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Article

Bias due to two-stage residual-outcome regression analysis in genetic association studies.

Genetic epidemiology - 1 Nov 2011

Demissie Serkalem, Cupples L Adrienne

Abstract excerpt

Association studies of risk factors and complex diseases require careful assessment of potential confounding factors. Two-stage regression analysis, sometimes referred to as residual- or adjusted-outcome analysis, has been increasingly used in association studies of single nucleotide polymorphisms (SNPs) and quantitative traits. In this analysis, first, a residual-outcome is calculated from a regression of the...

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Identifiers

PMID: 21769934
DOI: 10.1002/gepi.20607
PMCID: PMC3201714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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