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Article

Unveiling challenges in Mendelian randomization for gene-environment interaction.

Genetic epidemiology - 1 Jun 2024

Gorfine Malka, Qu Conghui, Peters Ulrike, Hsu Li

Abstract excerpt

Gene-environment (GxE) interactions play a crucial role in understanding the complex etiology of various traits, but assessing them using observational data can be challenging due to unmeasured confounders for lifestyle and environmental risk factors. Mendelian randomization (MR) has emerged as a valuable method for assessing causal relationships based on observational data. This approach utilizes genetic...

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PMID: 38420714
DOI: 10.1002/gepi.22552
PMCID: PMC11197907

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