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Article

Effect of selection bias on two sample summary data based Mendelian randomization.

Scientific reports - 7 Apr 2021

Wang Kai, Han Shizhong

Abstract excerpt

Mendelian randomization (MR) is becoming more and more popular for inferring causal relationship between an exposure and a trait. Typically, instrument SNPs are selected from an exposure GWAS based on their summary statistics and the same summary statistics on the selected SNPs are used for subsequent analyses. However, this practice suffers from selection bias and can invalidate MR methods, as showcased via two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33828182
DOI: 10.1038/s41598-021-87219-6
PMCID: PMC8027662

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