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Effects of matrix metalloproteinase (MMP)-2 polymorphisms on responsiveness to antihypertensive therapy of women with hypertensive disorders of pregnancy.

Basic & clinical pharmacology & toxicology - 1 Oct 2012

Palei Ana C T, Sandrim Valeria C, Amaral Lorena M, Machado Jackeline S R, Cavalli Ricardo C, Lacchini Riccardo, Duarte Geraldo, Tanus-Santos Jose E

Abstract excerpt

Imbalanced matrix metalloproteinase (MMP) expression, including MMP-2, has been demonstrated in pre-eclampsia. However, little is known about the effect of polymorphisms in MMP-2 gene on hypertensive disorders of pregnancy. We examined whether two functional MMP-2 polymorphisms (g.-1306C>T and g.-735C>T) are associated with pre-eclampsia and/or gestational hypertension and whether these polymorphisms affect...

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PMID: 22672240
DOI: 10.1111/j.1742-7843.2012.00905.x

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