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Article

Matrix metalloproteinase-2 -735C/T polymorphism is associated with resistant hypertension in a specialized outpatient clinic in Brazil.

Gene - 15 Jul 2017

Sabbatini Andrea R, Barbaro Natalia R, de Faria Ana Paula, Ritter Alessandra Mileni V, Modolo Rodrigo, Correa Nathália B, Brunelli Veridiana, Pinho Claudio, Fontana Vanessa, Moreno Heitor

Abstract excerpt

BACKGROUND: Matrix metalloproteinases (MMPs) are enzymes involved in cardiovascular (CV) remodeling and hypertension-mediated target organ damage (TOD). Genetic polymorphisms in matrix metalloproteinase 2 (MMP-2) gene [-1575G/A (rs243866); -1306C/T (rs243865); and -735C/T (rs2285053)] are associated with several CV conditions, however the relationship between MMP-2 polymorphisms and resistant hypertension (RH) is...

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PMID: 28390988
DOI: 10.1016/j.gene.2017.04.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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