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Article

Tissue inhibitor of matrix metalloproteinase-1 polymorphism, plasma TIMP-1 levels, and antihypertensive therapy responsiveness in hypertensive disorders of pregnancy.

The pharmacogenomics journal - 1 Dec 2014

Luizon M R, Palei A C T, Sandrim V C, Amaral L M, Machado J S R, Lacchini R, Cavalli R C, Duarte G, Tanus-Santos J E

Abstract excerpt

Tissue inhibitor of metalloproteinase (TIMP)-1 is a major endogenous inhibitor of matrix metalloproteinase (MMP)-9, which may affect the responsiveness to therapy in hypertensive disorders of pregnancy. We examined whether TIMP-1 polymorphism (g.-9830T>G, rs2070584) modifies plasma MMP-9 and TIMP-1 levels and the response to antihypertensive therapy in 596 pregnant: 206 patients with preeclampsia (PE), 183...

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PMID: 24913092
DOI: 10.1038/tpj.2014.26

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