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Article

Association of PGC-1alpha polymorphisms with age of onset and risk of Parkinson's disease.

BMC medical genetics - 19 May 2011

Clark Joanne, Reddy Sonika, Zheng Kangni, Betensky Rebecca A, Simon David K

Abstract excerpt

BACKGROUND: Peroxisome proliferator-activated receptor-γ co-activator (PGC)-1α is a transcriptional co-activator of antioxidant genes and a master regulator of mitochondrial biogenesis. Parkinson's disease (PD) is associated with oxidative stress and mitochondrial dysfunction and recent work sugg...

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Identifiers

PMID: 21595954
DOI: 10.1186/1471-2350-12-69
PMCID: PMC3112073

Genes

PGC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21595954-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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