Article
The chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) targets PTEN for proteasomal degradation.
The Journal of biological chemistry - 4 May 2012
Ahmed Syed Feroj, Deb Satamita, Paul Indranil, Chatterjee Anirban, Mandal Tapashi, Chatterjee Uttara, Ghosh Mrinal K
Abstract excerpt
The tumor suppressor, PTEN is key to the regulation of diverse cellular processes, making it a prime candidate to be tightly regulated. The PTEN level is controlled in a major way by E3 ligase-mediated degradation through the Ubiquitin-Proteasome System (UPS). Nedd 4-1, XIAP, and WWP2 have been shown to maintain PTEN turnover. Here, we report that CHIP, the chaperone-associated E3 ligase, induces ubiquitination...
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